文献类型：期刊文献

中文题名：亚麻籽对运动训练大鼠睾酮及相关激素含量和抗运动疲劳能力的影响

英文题名：Effects of Flaxseed on Testosterone Content,Correlated Hormones Content and Exercise Capacity in Rats Receiving Exercise Training

作者：文婧[1];冀颐之[2];谢飞[2]

第一作者：文婧

机构：[1]北京联合大学体育教学部;[2]北京联合大学生物化学工程学院

第一机构：北京联合大学体育教学部|北京联合大学体育部、体委

年份：2015

卷号：21

期号：12

起止页码：99-103

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD_E2015_2016】；

基金：北京市优秀人才培养项目(2012D005022000007)

语种：中文

中文关键词：亚麻籽;睾酮;皮质酮;促黄体生成素;促卵泡激素;抗疲劳

外文关键词：flaxseed; testosterone; corticosterone; luteinizing hormone; follicle-stimulating hormone; anti -fatigue

摘要：目的:研究亚麻籽对运动训练大鼠睾酮及相关激素含量和抗疲劳能力的影响。方法:以大强度耐力训练大鼠为模型,55只42 d龄雄性SPF级Wistar大鼠为对象,以数字随机分组法分为5组:静止组(C组)、运动组(M组)、运动+亚麻籽(FM)Ⅰ组(FMⅠ组),运动+亚麻籽Ⅱ组(FMⅡ组),运动+亚麻籽Ⅲ组(FMⅢ组),各组均为10只。每天ig 1次,亚麻籽组剂量分别为0.75,1.5,4.5 g·kg-1,ig体积为5 m L·kg-1,C,M组ig等量生理盐水。力竭游泳训练42 d后,分别测定各组大鼠体重、力竭游泳时间和血清睾酮等相关生化指标。结果:体重M组M组(P<0.05),且FM组间无显著差异。力竭游泳时间,M组与C组无明显差异;FM各组明显长于M组(P<0.01)。血清睾酮水平,M组低于C组(P<0.01);FM各组均高于M组(P<0.01),分别为(4.83±1.15),(4.93±1.13),(5.11±1.12)nmol·L-1,且组间无显著差异。血清皮质酮水平,C,M,FM各组间无显著差异。血清睾酮与皮质酮比值变化与睾酮变化较为一致。血清促黄体生成素、促卵泡激素水平,C组高于M组,但无显著差异;FM各组高于M组(P<0.05),且FM各组组间无显著差异。结论:补充亚麻籽可以纠正由于运动导致的下丘脑-垂体-性腺轴功能的紊乱,有效预防血清睾酮水平的降低,进而增强抗疲劳能力。
Objective： To study the effects of flaxseed on the content of testosterone, correlated hormones and anti-fatigue ability of rats after exercise. Method： By using the model of high-intensity endurance training, 55 6-week-old male Wistar rats were randomly divided into 5 groups, with 10 in each group （5 rats which did not meet the requirement were removed） ： control group （ C group） , motion group （ M group） , exercise ＋ ig low-dose flaxseed group （FM I group）, exercise ＋ ig middle-dose flaxseed group （FM lI group） , and exercise ＋ ig high-dose flaxseed group （FM llI group）. Gavage was performed using professional device once a day. The rats in flaxseed groups were gavaged with O. 75, 1.5, 4.5 g·kg^-1 with ig volume of 5 mL·kg^-1. The rats in C and M groups were given saline of same volume. After 42 days of exhaustive swimming training, body weight, swimming time and serum testosterone and other biochemical markers were measured. Result： Body weight of the rats in M groups was lower than that in C group （P 〈 0.05） , and in all doses of flaxseed groups was higher than in M group （ P 〈 0. 05 ） which did not show any differences between flaxseed groups. Swimming time in all doses of flaxseed groups was longer than in M group （P 〈 0.01 ） , and there were dose-response. Serum testosterone in M group was lower than C group （P 〈 0.01 ） , in the same time, serum testosterone was higher in all doses of flaxseed groups than M group [FMI （4.83±1.15） nmol·L^-1, FMⅡ （4.93 ±1.13） nmol .L-1, FMⅢ （5.11 ±1.12） nmol·L^-1,P 〈 0.01 ]. The serum corticosterone levels in each group showed no significant differences. Changes in the ratio of serum testosterone/corticosterone were more consistent with testosterone changes among the groups. There were no differences in luteinizing hormone and follicle-stimulating hormone between C group and M group. But luteinizing hormone in all doses of flaxseed groups was higher than in M group （P 〈 0. 05）. In mean time, follicle-stimulating hormone in all doses of flaxseed groups was higher than in M group （P 〈 0. 05）. There were no differences in both luteinizing hormone and follicle-stimulating hormone between groups in all doses of flaxseed groups. Conclusion： The supplement of flaxseed can alleviate the hypothalamus-pituitary-gonad axis function disorder caused by exercise through multiple targets and multiple ways. Finally, flaxseed can prevent the decrease of serum testosterone after high-intensity exercise and improve anti-fatigue ability.