文献类型：期刊文献

英文题名：Lactobacillaceae improve cognitive dysfunction via regulating gut microbiota and suppressing Aβ deposits and neuroinflammation in APP/PS1 mice

作者：Wu, Yusong[1];Niu, Xiaohui[1];Li, Peifan[1];Tong, Tong[1];Wang, Qinger[1];Zhang, Michael[2,3];Li, Yongli[4];Liu, Jia[5];Li, Zuming[1]

第一作者：Wu, Yusong

通讯作者：Li, ZM[1]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Beijing, Peoples R China;[2]Univ Manitoba, Dept Phys & Astron, Winnipeg, MB, Canada;[3]Sino Canada Hlth Engn Res Inst, Hefei, Peoples R China;[4]Zhengzhou Univ, Henan Prov Peoples Hosp, Peoples Hosp, Zhengzhou, Peoples R China;[5]Internal Trade Food Sci & Technol Beijing Co Ltd, Beijing, Peoples R China

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2023

卷号：205

期号：4

外文期刊名：ARCHIVES OF MICROBIOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001061294100002)】；

语种：英文

外文关键词：Alzheimer's disease; A beta deposits; Cognitive dysfunction; Gut microbiota; Lactobacillaceae; Neuroinflammation

摘要：Alzheimer's disease (AD), the most prevalent neurodegenerative disease, has a significant relationship with alteration of the gut microbiota (GM), and the GM-gut-brain axis has been explored to find novel therapeutic approaches for AD. The present study aimed to evaluate the effect of human Lactobacillaceae (HLL) on cognitive function in APP/PS1 mice. The results showed that HLL treatment significantly improved the cognitive function of mice via MWM and NOR tests. Furthermore, the expression of A beta plaques, tau phosphorylation and neuroinflammation were markedly reduced in the hippocampus. Meanwhile, HLL treatment significantly increased the activity of GSH-PX and decreased the expression levels of IL-6 and MDA in the brain, and simultaneously increased the abundance of beneficial bacteria and restrained pathogenic bacteria in the intestine. Interestingly, significant correlations were observed between significant changes in abundance of GMs and AD-related markers. Collectively, these findings reveal that HLL is a promising therapeutic agent and potential probiotics, which might improve the cognitive function and AD pathologies.