文献类型：期刊文献

英文题名：Investigation of the sustained-release mechanism of hydroxypropyl methyl cellulose skeleton type Acipimox tablets

作者：Liu, Wanying[1];Huo, Qing[1];Wang, Yue[1];Yu, Na[1];Shi, Rongjian[2]

第一作者：Liu, Wanying

通讯作者：Huo, Q[1]

机构：[1]Beijing Union Univ, Dept Biomed, Biochem Engn Coll, Fatou Xili 3 Reg 18, Beijing 100023, Peoples R China;[2]Chinese Acad Sci, Res & Dev Ctr, Inst High Energy Phys, Yuquan Rd 19hao, Beijing 100049, Peoples R China

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Dept Biomed, Biochem Engn Coll, Fatou Xili 3 Reg 18, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2018

卷号：16

期号：1

起止页码：333-339

外文期刊名：OPEN CHEMISTRY

收录：;Scopus(收录号：2-s2.0-85046535705);WOS:【SCI-EXPANDED(收录号:WOS:000431899300005)】；

基金：This work was supported by the National Natural Science Foundation of China #1 under Grant number 11475020; the National Natural Science Foundation of China #2 under Grant number 8151114029; and Building virtual teaching and researching team to enhance teaching quality and project #3 under Grant number PXM2016_014209_000023. Chaoyang District collaborative innovation project #4 under Grant number 2016-8.

语种：英文

外文关键词：Acipimox; sustained-release tablet; sodium carboxymethylcellulose; hydroxypropyl methyl cellulose

摘要：In this study, we investigate the production of hypolipidemic agents in the form of Acipimox sustained-release tablets, using a wet pelleting process. The purpose of this research is to reduce the total intake time for patients and to lower the initial dose in such that the adverse reactions could be reduced. This study adopts the single-factor method and orthogonal experiments by using hydroxypropyl methyl cellulose (HPMC K15M) as the main sustained-release prescription composition. The final prescription is Acipimox 20%, HPMC K15M 26.67%, sodium carboxymethyl cellulose 30%, polyethylene glycol (PEG 6000) 1%, ethyl cellulose 16.6%, lactose 4.67% and magnesium stearate 1%. The dissolution of tablets reached 85.88% in 8 h. The difference in the weight, hardness and friability of the tables met the requirements in the Chinese Pharmacopoeia; to test the stability, a temperature and illumination accelerated test method was used, the results indicate that the Acipimox sustained-release tablets should be sealed and stored in a dark, cool area. A preliminary study on the tablets' releasing mechanism showed that their release curve fitted the Higuchi model (the formula is M-t/M-infinity = 31.137 t(1/)(2)-3.605 (R-2 = 0.9903)). The Acipimox tablets' release principle is dominated by the diffusion mechanism.