文献类型：期刊文献

英文题名：Lactiplantibacillus plantarum BW2013 protects mucosal integrity and modulates gut microbiota of mice with colitis

作者：Niu, Xiaohui[1,2];Li, Qian[1,2];Luan, Na[1,2];Liu, Jia[3];Zhang, Michael[4];An, Jun[1,2,5];Li, Zuming[1,2];Bai, Zhihui[6];Xia, Ran[3];Wu, Zhichao[3]

第一作者：Niu, Xiaohui

通讯作者：Li, ZM[1];Li, ZM[2]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Dept Food Sci, Beijing 100023, Peoples R China;[2]Beijing Union Univ, Coll Biochem Engn, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100023, Peoples R China;[3]Internal Trade Food Sci & Technol Beijing Co Ltd, Beijing 102209, Peoples R China;[4]Univ Manitoba, Dept Phys & Astron, Winnipeg, MB R3T 2N2, Canada;[5]Zhejiang Yangshengtang Nat Med Res Inst Co Ltd, Hangzhou 310024, Peoples R China;[6]Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China

第一机构：北京联合大学生物化学工程学院食品科学系

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Dept Food Sci, Beijing 100023, Peoples R China;[2]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100023, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;[11417146]北京联合大学生物化学工程学院食品科学系;

年份：2023

卷号：69

期号：4

起止页码：158-169

外文期刊名：CANADIAN JOURNAL OF MICROBIOLOGY

收录：;Scopus(收录号：2-s2.0-85154018849);WOS:【SCI-EXPANDED(收录号:WOS:000962874500002)】；

基金：Funding information This study was supported by Beijing Natural Science Founda- tion (grant number 6173033) and Academic Research Projects of Beijing Union University (grant number ZK70202003) .

语种：英文

外文关键词：ulcerative colitis; mucosal integrity; gut microbiota; L; plantarum

摘要：This study explored the effects of Lactiplantibacillus plantarum (previously Lactobacillus plantarum) BW2013 on mucosal integrity and gut microbiota of mice with dextran sulfate sodium (DSS)-induced colitis. The results show that the clinical symptoms in DSS-modelled ulcerative colitis (UC) were improved by L. plantarum BW2013 via decreasing disease activity index scores and suppressing inflammatory cell infiltration. Furthermore, L. plantarum BW2013 decreased the levels of diamine oxidase activity, myeloperoxidase, and D-lactic acid. The mRNA expression of ZO-1, occludin, and claudin-1 was upregulated by L. plantarum BW2013, which also increased IL-10 and reduced TNF-alpha, IL-1 beta, and IL-6 in the colon. 16S rDNA sequencing showed that L. plantarum BW2013 enhanced alpha-diversity. L. plantarum BW2013 upregulated significantly the abundance of unidentfied Lachnospiraceae, Lactococcus, Rikenella, Lactobacillus, and Odoribacter, which had an inhibitory effect on inflammation and a protective effect on the integrity of the mucosa. These results demonstrate that L. plantarum BW2013 alleviates DSS-modelled UC by protecting mucosal integrity and ameliorating the composition of gut microbiota.