文献类型：期刊文献

中文题名：类胡萝卜素与癌症风险相关性的研究

英文题名：Relationship Between Carotenoids and Cancer Risk

作者：翟艳丽[1];惠伯棣[1];蔡靳[2];刘蕊[3];王英明[3]

第一作者：翟艳丽

机构：[1]北京联合大学应用文理学院食品科学系;[2]河北大学生命科学学院;[3]新疆红帆生物科技有限公司

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院食品科学系

年份：2013

卷号：34

期号：13

起止页码：307-313

中文期刊名：食品科学

外文期刊名：Food Science

收录：CSTPCD;;Scopus;北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

基金："十一五"国家科技支撑计划项目(2008BAI58B06)

语种：中文

中文关键词：类胡萝卜素;癌症;膳食;摄入量;预防

外文关键词：carotenoid; cancer; dietary pattern; intake; preventive effect

摘要：通过综述多种研究的结论试图论证类胡萝卜素和癌症发病率之间的关系。这些研究是在多个水平上展开的,包括分子、细胞、动物模型、临床以及流行病学水平。得出的结论可概括为:增加富含类胡萝卜素化合物的食物的摄入量可影响细胞生长失调和癌变中发生的生物和生化进程,从而在某种程度上降低癌症发病的风险。但该结论并不适用于所有癌症。总之,膳食类胡萝卜素在降低癌症发病风险上将会有很现实的意义。由于流行病学研究数据的可信度不高以及动物模型与人体的差异等因素,这一结论能在人类征服癌症的漫长过程中起到多大的作用还值得商榷。
Through an extensive review of the literature,this article attempts to demonstrate the relationship between carotenoids and cancer risk.These studies were conducted on the multiple levels such as molecular,cellular,animal,clinical and epidemiological levels.Conclusions made from these studies can be outlined as： an increased amount of diets rich in carotenoids was able to have an influence on biological and biochemical processes involved in the development of cell growth dysregulation and carcinogenesis and reduced the risk of cancer.However,this conclusion was not analogous between cancers.Anyway,it has a practical significance for dietary carotenoid-induced cancer risk reduction.Due to the poor reliability of epidemiological study and difference between animal and clinical trails,this conclusion is going to be questionable on a long way to conquer cancer.