文献类型：期刊文献

中文题名：牛蒡子对运动训练大鼠睾酮及相关激素含量和抗运动疲劳能力的影响

英文题名：Effect of Arctii Fructus on Testosterone Content,Correlated Hormones Content and Exercise Capacity in Rats Receiving Exercise Training

作者：娄春善[1];曹建民[2];郭娴[2];周海涛[3]

第一作者：娄春善

机构：[1]河北师范大学;[2]北京体育大学;[3]北京联合大学生物化学工程学院

第一机构：河北师范大学,石家庄050024

年份：2015

卷号：21

期号：4

起止页码：153-157

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD_E2015_2016】；

基金：河北省教育厅重点项目(ZD20131100)

语种：中文

中文关键词：牛蒡子;睾酮;皮质酮;促黄体生成素;促卵泡激素;抗疲劳

外文关键词：Arctii Fructus; testosterone; corticosterone ; luteinizing hormone ; follicle-stimulating hormone ;anti-fatigue

摘要：目的:研究牛蒡子对运动训练大鼠睾酮及相关激素含量和抗疲劳能力的影响。方法:以大强度耐力训练大鼠为模型,55只42 d龄雄性Wistar大鼠为对象,随机分为5组:静止组(C组)、运动组(M组)、运动+低剂量牛蒡子组(AML组),运动+中剂量牛蒡子组(AMM组),运动+高剂量牛蒡子组(AMH组),每组10只(剔除不符合实验要求的大鼠5只)。每天灌胃ig给药1次,牛蒡子组剂量分为0.5,1,3 g·kg-1,ig体积为5 m L·kg-1,C,M组ig等量生理盐水。42 d力竭游泳训练后,测定体重、力竭游泳时间及血睾酮等生化指标。结果:体重,运动组小于静止组(P<0.05);牛蒡子各组>运动组(P<0.05)。力竭游泳时间,运动组与静止组无明显差异;牛蒡子各组明显长于运动组(P<0.01),且随剂量增大而延长。血清睾酮水平,运动组为(3.51±1.46)nmol·L-1低于静止组(P<0.01);牛蒡子低、中、高剂量组分别为(4.85±1.54),(4.97±1.47),(5.07±1.56)nmol·L-1,高于运动组(P<0.01)。血清皮质酮水平,各组间均无显著差异。血清睾酮与皮质酮比值变化与睾酮变化较为一致。血清促黄体生成素、促卵泡激素水平,静止组与运动组无显著差异;牛蒡子各组高于运动组(P<0.05)。结论:补充牛蒡子可以从多靶点、多途径纠正由于运动导致的下丘脑-垂体-性腺轴功能的紊乱,有效预防血清睾酮水平的降低,进而增强抗疲劳能力。
Objective： To study the effects of Arctii Fructus on the content of testosterone, correlated hormones and anti-fatigue ability of rats after exercise. Method： By using the model of high-intensity endurance training, fifty-five 6-week-old male Wistar rats were randomly divided into 5 groups, with 10 in each group （5 rats which did not meet the requirement were removed） ： still in control group （ C group） , motion control group （ M group）, exercise ＋ ig low-dose Arctii Fructus group （AML group）, exercise ＋ ig middle-dose Arctii Fructus group （AMM group）, and exercise ＋ ig high-dose Arctii Fruetus group （AMH group）. Garage was performed using professional device once a day. The rats in Arctii Fructus groups were garaged wth 0.5, 1, 3 g·kg^-1 with ig volume of 5 mL·kg^-1 The rats in C and M groups were given saline of same volume. After 42 days of exhaustive swimming training, body weight, swimming time and serum testosterone and other biochemical markers were measured. Result： Body weight of the rats in M groups lower than that in C group （P〈0.05）, and that in all doses of Arctii Fructus groups was higher than in M group （P 〈 0.05） which did not show any differences between groups. Swimming time in all doses of Arctii Fructus groups was longer than in M group （P 〈 0.01 ） , and there were dose-response. But there were no differences between C and M groups. Serum testosterone in M group was lower than C group （P 〈 O. O1 ） , in the same time, serum testosterone was higher in all doses of Arctii Fructus groups than M group （P 〈0. 01）. The serum eorticosterone levels in each group showed no significant differences. Changes in the ratio of serum testosterone/eorticosterone were more consistent with testosterone changes among the groups. There were no differences in luteinizing hormone and follicle-stimulating hormone between C group and M group. But luteinizing hormone in all doses of Arctii Fructus groupswas higher than in iV[ group （P 〈 O. 05）. In the mean tinle, follicle-stimulating hormone in all doses of Aretii Fruetus groups was higher than in M group （P 〈0. 05）. There were no differences in both luteinizing hormone and follicle-stimulating hormone between groups in all doses of Arctii Fructus groups and there were dose-response. Conclusion： The supplement of Arctii Fructus can alleviate the hypothalamus- pituitary-gonad axis function disorder caused by exercise through muhiple targets and multiple ways. Arctii Fructus can prevent the decrease of serum testosterone after high-intensity exercise and improve anti-fatigue ability.