文献类型：期刊文献

英文题名：The synergism of Lactobacillaceae, inulin, polyglucose, and aerobic exercise ameliorates hyperglycemia by modulating the gut microbiota community and the metabolic profiles in db/db mice

作者：Li, Peifan[1];Tong, Tong[1];Shao, Xinyu[1];Han, Yan[1];Zhang, Michael[2,3];Li, Yongli[4];Lv, Xue[4];Li, Hao[5];Li, Zuming[1]

第一作者：Li, Peifan

通讯作者：Li, ZM[1];Li, H[2]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China;[2]Univ Manitoba, Dept Phys & Astron, Winnipeg, MB R3T 2N2, Canada;[3]Sino Canada Hlth Engn Res Inst, Hefei, Peoples R China;[4]Zhengzhou Univ, Henan Prov Peoples Hosp, Peoples Hosp, Zhengzhou 450003, Peoples R China;[5]Fuwai Cent China Cardiovasc Hosp, Zhengzhou 450003, Peoples R China

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China;[2]corresponding author), Fuwai Cent China Cardiovasc Hosp, Zhengzhou 450003, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2024

外文期刊名：FOOD & FUNCTION

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001203462400001)】；

基金：This work was supported by the National Key Research and Development Plan (2022YFC2010000 and 2022YFC2010001), the Academic Research Projects of Beijing Union University under Grant ZK20202307 and the Sino Canada Health Engineering Research Institute Cooperation Projects under Grant 50304JA1901.

语种：英文

摘要：This study aimed to assess the impact of Lactobacillaceae (L or H represents a low or high dose), inulin (I), and polydextrose (P) combined with aerobic exercise (A) on the composition of the gut microbiota and metabolic profiles in db/db mice. After a 12-week intervention, LIP, LIPA, and HIPA groups exhibited significant improvements in hyperglycemia, glucose tolerance, insulin resistance, inflammatory response, and short-chain fatty acid (SCFA) and blood lipid levels compared to type 2 diabetes mice (MC). After treatment, the gut microbiota composition shifted favorably in the treatment groups which significantly increased the abundance of beneficial bacteria, such as Bacteroides, Blautia, Akkermansia, and Faecalibaculum, and significantly decreased the abundance of Proteus. Metabolomics analysis showed that compared to the MC group, the contents of 5-hydroxyindoleacetic acid, 3-hydroxysebacic acid, adenosine monophosphate (AMP), xanthine and hypoxanthine were significantly decreased, while 3-ketosphinganine, sphinganine, and sphingosine were significantly increased in the LIP and LIPA groups, respectively. Additionally, LIP and LIPA not only improved sphingolipid metabolism and purine metabolism pathways but also activated AMP-activated protein kinase to promote beta-oxidation by increasing the levels of SCFAs. Faecalibaculum, Blautia, Bacteroides, and Akkermansia exhibited positive correlations with sphingosine, 3-ketosphinganine, and sphinganine, and exhibited negative correlations with hypoxanthine, xanthine and AMP. Faecalibaculum, Blautia, Bacteroides, and Akkermansia may have the potential to improve sphingolipid metabolism and purine metabolism pathways. These findings suggest that the synergism of Lactobacillaceae, inulin, polydextrose, and aerobic exercise provides a promising strategy for the prevention and management of type 2 diabetes.