文献类型：期刊文献

英文题名：The beneficial effects of taurine in alleviating fatty liver disease

作者：Song, Qi[1];Guo, Junxia[1];Zhang, Yanzhen[1];Chen, Wen[1]

通讯作者：Chen, W[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beituchengxi Rd 197, Beijing 100191, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beituchengxi Rd 197, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2021

卷号：77

外文期刊名：JOURNAL OF FUNCTIONAL FOODS

收录：;Scopus(收录号：2-s2.0-85099238793);WOS:【SCI-EXPANDED(收录号:WOS:000614471000002)】；

基金：This work was supported by opening foundation of Beijing Key Laboratory of Bioactive Substances and Functional Food of Beijing Union University and the Academic Research Projects of Beijing Union University (No.XP202005).

语种：英文

外文关键词：Taurine; Alcoholic fatty liver disease (AFLD); Non-alcoholic fatty liver disease (NAFLD)

摘要：Fatty liver disease (FLD) is mainly characterized by the pathophysiological progression from simple hepatic steatosis to steatohepatitis, which has been increasing in incidence and has attracted much attention due to its risk of hepatocellular carcinoma. It is considered that lipid metabolism disorder, oxidative stress, inflammation etc. are common factors leading to the progression of FLD including alcoholic fatty liver disease (AFLD) and nonalcoholic fatty liver disease (NAFLD). A number of studies provide the evidence that taurine, a small sulfur containing amino acid in food, has the efficient action to FLD. The beneficial effects include lowering lipids level to alleviate hepatic steatosis, increasing the antioxidant enzymes and substances to improve antioxidant defense, regulating the inflammation-related signal pathways to reduce pro-inflammatory factors and inflammatory response, and regulating the enzymes involved in ethanol metabolism etc. This review summarizes the data from in vivo and in vitro studies, and addresses the possible metabolic and molecular mechanisms of taurine in alleviating FLD.