文献类型：期刊文献

英文题名：Optimizing the Formulation for Ginkgolide B Solid Dispersion

作者：Wu, Xiao[2];Huo, Qing[1];Quan, Qizhe[3];Yang, Xiaofang[3];Yu, Na[3];Wang, Yue[4]

通讯作者：Huo, Q[1]

机构：[1]Beijing Union Univ, Dept Biomed, Beijing 100023, Peoples R China;[2]Beijing Union Univ, Dept Food Sci, Beijing 100023, Peoples R China;[3]Beijing Union Univ, Dept Pharmaceut Engn, Beijing 100023, Peoples R China;[4]Beijing Union Univ, Dept Bioengn, Beijing 100023, Peoples R China

第一机构：北京联合大学

通讯机构：[1]corresponding author), Beijing Union Univ, Dept Biomed, Beijing 100023, Peoples R China.|[11417]北京联合大学;

年份：2018

卷号：13

期号：1

起止页码：253-262

外文期刊名：OPEN LIFE SCIENCES

收录：;Scopus(收录号：2-s2.0-85053354736);WOS:【SCI-EXPANDED(收录号:WOS:000443295200002)】；

基金：This work was financially supported by National Natural Science Foundation of China (Grant No. 11475020 and No. 81511140298), project of Chaoyang district collaborative innovation (No. XC1608) and Beijing Union University Graduate Program.

语种：英文

外文关键词：Ginkgolide B; Solid dispersion; Rate of dissolution; Crystal

摘要：The main purpose of our study is to optimize the formulation for Ginkgolide B (GB) solid dispersion in order to improve its dissolution in water. For the preparation of GB solid dispersion, we use a solvent method. The optimized formulation consists of GB : PVPIC30 = 1:10, PVPIC30 as the carrier, and ethanol : dichloromethane = 1:1 as the solvent. They were treated ultrasonically for 10 min at 60 degrees C. The results from scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and particle size analysis show that the morphological appearance of GB changed significantly in solid dispersion. The original crystal form of GB no longer existed, but it was uniformly dispersed within PVPIC30 in a non-crystalline form. It is probably because the center dot C=O in GB forms hydrogen bonds with the center dot OH of PVPIC30 or urea; this produces a nice solid dispersion and significantly improves the dissolution of GB in water. When GB is in a solid dispersion system, GB's dissolution in water could be enhanced from 30% to 80%. Furthermore, it may even be produced as a solid agent.