文献类型：期刊文献

英文题名：Near-infrared fluorescent carbon dots encapsulated liposomes as multifunctional nano-carrier and tracer of the anticancer agent cinobufagin in vivo and in vitro

作者：Ren, Wei[1,4];Chen, Shiqing[2,3];Liao, Yuyang[4];Li, Shumu[1];Ge, Jiechao[2,3];Tao, Fengyun[4];Huo, Qing[4];Zhang, Yangyang[1,5];Zhao, Zhenwen[1,5]

第一作者：Ren, Wei

通讯作者：Zhang, YY[1];Zhao, ZW[1]

机构：[1]Chinese Acad Sci, CAS Res Educ Ctr Excellence Mol Sci, Beijing Mass Spectrum Ctr,Inst Chem, Beijing Natl Lab Mol Sci,Key Lab Analyt Chem Livi, Beijing 100190, Peoples R China;[2]Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China;[3]Chinese Acad Sci, Tech Inst Phys & Chem, CityU CAS Joint Lab Funct Mat & Devices, Beijing 100190, Peoples R China;[4]Beijing Union Univ, Coll Biochem Engn, Beijing 100023, Peoples R China;[5]Univ Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China

第一机构：Chinese Acad Sci, CAS Res Educ Ctr Excellence Mol Sci, Beijing Mass Spectrum Ctr,Inst Chem, Beijing Natl Lab Mol Sci,Key Lab Analyt Chem Livi, Beijing 100190, Peoples R China

通讯机构：[1]corresponding author), Chinese Acad Sci, CAS Res Educ Ctr Excellence Mol Sci, Beijing Mass Spectrum Ctr,Inst Chem, Beijing Natl Lab Mol Sci,Key Lab Analyt Chem Livi, Beijing 100190, Peoples R China.

年份：2019

卷号：174

起止页码：384-392

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000459840800045)】；

基金：This work is supported by the National Natural Science Foundation of China [grant numbers 21575146, 21874142, 21635008, 21621062 and 51472252].

语种：英文

外文关键词：Carbon dots; Cinobufagin; Multifunctional liposomes; Photoluminescence enhancement; Bio-imaging; Drug delivery

摘要：Integrating the optical properties of near-infrared fluorescent carbon dots into liposomes may construct a multifunctional nano-system with the potential as a drug carrier, tracer and efficacy intensifier of the anticancer agent. In this study, the liposomes loaded with hydrophilic near-infrared carbon dots as a nano-carrier and tracer of lipophilic anticancer agent cinobufagin were developed. Prepared liposomes were characterized by particle size, morphology and entrapment efficiency. The drug release behavior, the tracer function, the anticancer effect and the side effect were investigated in vitro and in vivo. It was observed that the photoluminescence emission of carbon dots could be strongly enhanced up to 5 times by nano-liposomes. Due to this property, the bio-imaging of CDs + CB liposomes in vitro and in vivo could be clearly obtained. Our results also showed that the CDs + CB liposomes could be uptaken by cells (the lysosomes targeted) and delivered to the tumor site, and undoubtedly, the CDs + CB liposomes demonstrated sustained drug release, enhanced anticancer efficacy and low side effects in vivo. With the assistance of imaging function of CDs, the CDs + CB liposomes can easily display the distribution of drugs, which is very helpful for drug development and may open a novel avenue for drug delivery.