文献类型：期刊文献

英文题名：Triterpenoids from Ainsliaea yunnanensis Franch. and their biological activities

作者：Li, Jinjie[1,2];Zhang, Bo[3];Liu, Hailing[4];Zhang, Xuan[5];Shang, Xiaoya[6];Zhao, Changqi[7]

第一作者：李金杰;Li, Jinjie

机构：[1]Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing, 100875, China;[2]Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, 100191, China

第一机构：Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing, 100875, China

通讯机构：[2]Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, 100191, China|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2016

卷号：21

期号：11

外文期刊名：Molecules

收录：MEDLINE(收录号：27827998);;Scopus(收录号：2-s2.0-84997605075);PubMed

语种：英文

外文关键词：Activity; Ainsliaea yunnanensis; NMR; Structures; Triterpenoids

摘要：One new pentacyclic triterpenoid, 3β-carboxylicfilic-4(23)-ene (1), and three known pentacyclic triterpenoids, adian-5-en-3α-ol (2), fernenol (3), and fern-7-en-3β-ol (4) were isolated from the petroleum ether phase of the ethanolic extract of Ainsliaea yunnanensis Franch. Their structures were established by spectroscopic methods including 1-D and 2-D NMR, and MS experiments. Compounds 1, 2, 3, and 4 showed significant selective cytotoxicity against human acute monocytic leukemia cell line (THP-1) with IC50 values of 5.12 μM, 1.78 μM, 1.74 μM, and 1.75 μM, respectively. Compound 1 also showed an anti-inflammatory effect through the inhibition of the activity of NF-κB by blocking the nuclear translocation of p65. ? 2016 by the authors; licensee MDPI.