文献类型：期刊文献

英文题名：Monascustin, an Unusual gamma-Lactam from Red Yeast Rice

作者：Wei, Wendi[1];Lin, Sheng[2,3];Chen, Minghua[2,3];Liu, Tianxi[4];Wang, Ali[1];Li, Jinjie[1];Guo, Qinglan[2,3];Shang, Xiaoya[1]

第一作者：Wei, Wendi

通讯作者：Shang, XY[1]

机构：[1]Beijing Union Univ, Beiijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China;[2]Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China;[3]Peking Union Med Coll, Beijing 100050, Peoples R China;[4]Lanzhou Univ, Affiliated Hosp 1, Lanzhou 730000, Gansu, Peoples R China

第一机构：北京联合大学应用文理学院|北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beiijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.|[114172]北京联合大学应用文理学院;[11417]北京联合大学;[1141726]北京联合大学生物化学工程学院;

年份：2017

卷号：80

期号：1

起止页码：201-204

外文期刊名：JOURNAL OF NATURAL PRODUCTS

收录：;Scopus(收录号：2-s2.0-85010911743);WOS:【SCI-EXPANDED(收录号:WOS:000393089600027)】；

基金：Financial support from the National Natural Sciences Foundation of China (NNSFC; Grant No. 31171669), Beijing Natural Sciences Foundation (Grant No. 7142028), and Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University (Grant No. Zk60201601) is acknowledged.

语种：英文

摘要：Monascustin (1), an unusual gamma-lactam, was isolated from an ethanol extract of the Monascus purpureus fermented rice. Its structure including the absolute configuration was, determined by spectroscopic data analysis and confirmed by X-ray crystallography. A plausible biosynthetic pathway is discussed on the basis of amino acid derivatization. Compound 1 showed inhibitory activity against histone deacetylase 1.