文献类型：期刊文献

英文题名：The effect of taurine on cholesterol metabolism

作者：Chen, Wen[1];Guo, Jun-Xia[1];Chang, Ping[1]

第一作者：陈文

通讯作者：Chen, W[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China

第一机构：北京联合大学生物化学工程学院|北京联合大学应用文理学院

通讯机构：[1]corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beituchengxi Rd 197, Beijing 100191, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;[114172]北京联合大学应用文理学院;

年份：2012

卷号：56

期号：5

起止页码：681-690

外文期刊名：MOLECULAR NUTRITION & FOOD RESEARCH

收录：;Scopus(收录号：2-s2.0-84861689126);WOS:【SCI-EXPANDED(收录号:WOS:000304598000001)】；

语种：英文

外文关键词：Bile acid; Cholesterol; Cholesterol 7a-hydroxylase; Low density lipoprotein receptor; Taurine

摘要：The elevated plasma cholesterol level, in particular, LDL cholesterol is regarded as an important risk factor for the development of atherosclerosis and coronary artery disease. A number of studies provide the evidence that taurine has the efficient action to reduce plasma and liver cholesterol concentrations, especially to decrease VLDL and LDL cholesterol in hypercholesterolemia animal induced by high cholesterol diet. Cholesterol lowering effect of taurine is actually involved in the regulatory mechanism of cholesterol and bile acid homeostasis that mediated by CYP7A1, which has become a biomarker for cholesterol metabolism and itself is also regulated by several factors and nuclear receptors. This review summarizes the change of cholesterol concentration in metabolism observed in feeding studies of hypercholesterolemia animal dealing with taurine, and then, addresses the possible metabolic and molecular mechanisms of cholesterol lowering effect by taurine in three aspects, cholesterol clearance from blood circulation, bioconversion of cholesterol to bile acid in liver, and excretion of cholesterol and bile acid from intestine.