文献类型：期刊文献

英文题名：Functional food potential of Cornus officinalis for liver health: mechanistic evidence and perspectives

作者：Liu, Bo[1];He, Yi[1];Ma, Xuan[1];Zhao, Chenrui[1];Chen, Qin[1];Li, Yundan[1];Heng, Jiangying[1];Zhang, Yu[1];Jin, Jing[1];Wang, Feng[1]

通讯作者：Wang, F[1]

机构：[1]Beijing Union Univ, Coll Biochem Engn, Beijing 100032, Peoples R China

第一机构：北京联合大学生物化学工程学院

通讯机构：[1]corresponding author), Beijing Union Univ, Coll Biochem Engn, Beijing 100032, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2026

卷号：15

期号：2

外文期刊名：FOOD SCIENCE AND HUMAN WELLNESS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001715602600001)】；

基金：This research was funded by the Major Science and Technology Project of Henan Province (231100310200), and the National Key Research and Development Program (2023YFF1103804). The authors gratefully acknowledge the assistance provided by the Figdraw drawing software.

语种：英文

外文关键词：Cornus officinalis; Hepatoprotective effect; Mechanism of action; Functional food

摘要：Liver diseases remain a global health crisis, with limited safe therapeutic options. Cornus officinalis, a traditional medicinal-edible plant, has demonstrated significant hepatoprotective potential. This review systematically summarizes its liver-protective mechanisms and explores its potential as a functional food. Data were collected from scientific databases such as PubMed, ScienceDirect, Elsevier, Google Scholar, and relevant literature. Key bioactive compounds-including iridoids, polyphenols, and polysaccharides-contribute to hepatoprotection by mitigating oxidative stress, inflammation, steatosis, apoptosis, and by regulating gut microbiota. As critical quality markers, iridoids exhibit suboptimal bioavailability, necessitating targeted technological interventions-nanoencapsulation for liver-specific delivery and microbial fermentation for controlled aglycone conversion are proposed to enhance their pharmacokinetic properties and bioactivity. Future research could adopt encapsulation and fermentation technologies for C. officinalis processing, aiming to develop targeted functional food products with enhanced bioactivity of its active components. This review, for the first time, establishes a "component-pathway-integration" model, providing a theoretical framework for evidence-based CO-derived functional food development and highlighting the need for further research on iridoid metabolic transformation to advance liver health management.