文献类型：期刊文献

英文题名：Prebiotic, Immunomodulating, and Antifatigue Effects of Konjac Oligosaccharide

作者：Zeng, Yan[1];Zhang, Jiangang[1];Zhang, Ying[1];Men, Yan[1];Zhang, Bo[2];Sun, Yuanxia[1]

第一作者：Zeng, Yan

通讯作者：Sun, YX[1]

机构：[1]Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Engn Lab Ind Enzymes, Tianjin 300308, Peoples R China;[2]Beijing Union Univ, Coll Biochem Engn, Key Lab Bioact Mat & Funct Food Beijing, Beijing 100023, Peoples R China

第一机构：Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Engn Lab Ind Enzymes, Tianjin 300308, Peoples R China

通讯机构：[1]corresponding author), Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Engn Lab Ind Enzymes, Tianjin 300308, Peoples R China.

年份：2018

卷号：83

期号：12

起止页码：3110-3117

外文期刊名：JOURNAL OF FOOD SCIENCE

收录：;Scopus(收录号：2-s2.0-85058062464);WOS:【SCI-EXPANDED(收录号:WOS:000452797900027)】；

基金：We are grateful for the financial support from Natl. Science and Technology Major Project of China (2017YFD0200902) and the Key Research and Development Program of Jiangxi Province of China (20171ACH80014).

语种：英文

外文关键词：antifatigue effect; immunostimulating activity; konjac oligosaccharide; prebiotic potential

摘要：Irregular and long time work schedules not only makes people feel fatigue, but also brings great risks of diseases, due to gastrointestinal disorder and immune dysfunction. Therefore, it has positive significance to help challenged people stay energetic and healthy with food supplement. Konjac oligosaccharide has shown various physiological benefits and been recommended in the fortification of functional foods. However, there have been few reports on its application aimed to simultaneously relieve physical fatigue and keep body healthy. In this paper, the potential prebiotic, immunoregulatory, and antifatigue activities of konjac oligosaccharide were evaluated in vitro and in vivo. The results showed that konjac oligosaccharide could promote probiotics growth and short chain fatty acids production in mice cecum. At the concentration of 50 to 200 mu g/mL, konjac oligosaccharide could activate murine macrophage RAW 264.7 to secret NO and cytokines of IL-10 and IL-6. Moreover, this oligosaccharide could alleviate physical fatigue by prolonging exhaustive time, improving the level of superoxide dismutases and glutathione peroxidase, increasing the content of blood glucose, and decreasing the content of blood urea nitrogen. The results suggested that konjac oligosaccharide had prebiotic, immunoregulatory, and antifatigue effects, providing its application potential in functional food aimed at people with irregular and long time work.