文献类型：期刊文献

英文题名：Regulation of Magnesium Matrix Composites Materials on Bone Immune Microenvironment and Osteogenic Mechanism

作者：Nie, Xiaojing[1];Zhang, Xueyan[2,3];Lei, Baozhen[2,3];Shi, Yonghua[1];Yang, Jingxin[2,3]

第一作者：Nie, Xiaojing

通讯作者：Nie, XJ[1];Yang, JX[2];Yang, JX[3]

机构：[1]Xinjiang Med Univ, Sch Basic Med Sci, Dept Pathol, Urumqi, Peoples R China;[2]Beijing Union Univ, Beijing Engn Res Ctr Smart Mech Innovat Design Se, Beijing, Peoples R China;[3]Beijing Union Univ, Coll Robot, Beijing, Peoples R China

第一机构：Xinjiang Med Univ, Sch Basic Med Sci, Dept Pathol, Urumqi, Peoples R China

通讯机构：[1]corresponding author), Xinjiang Med Univ, Sch Basic Med Sci, Dept Pathol, Urumqi, Peoples R China;[2]corresponding author), Beijing Union Univ, Beijing Engn Res Ctr Smart Mech Innovat Design Se, Beijing, Peoples R China;[3]corresponding author), Beijing Union Univ, Coll Robot, Beijing, Peoples R China.|[1141739]北京联合大学机器人学院;[11417]北京联合大学;

年份：2022

卷号：10

外文期刊名：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY

收录：;EI(收录号：20221511942113);Scopus(收录号：2-s2.0-85127682812);WOS:【SCI-EXPANDED(收录号:WOS:000778642000001)】；

基金：This work was supported by the Academic Research Projects of Beijing Union University (No.ZK70202006) and Beijing Youth top individual project (2016000026833ZK04), the National Natural Science Foundation of China (No. 5177050098), the collaborative innovation project of Chaoyang District, Beijing (CYXC2102). Xinjiang Uygur Autonomous Region Youth Science Foundation Project (2022D01C208).

语种：英文

外文关键词：magnesium; functionalmaterials; coating; osteogenesis; osteogenic mechanism; bone immunity

摘要：Despite magnesium based metal materials are widely used in bone defect repair, there are still various deficiencies, and their properties need to be optimized. Composites synthesized with magnesium based metal as matrix are the research hotspot, and the host immune response after biomaterial implantation is very important for bone binding. By studying the immunoregulation of bone biomaterials, it can regulate the immune response in the process of osteogenesis and create a good local immune microenvironment, which is conducive to biomaterials to reduce inflammatory response and promote good bone binding. This article introduces the osteogenic mechanism of magnesium based metal materials and its regulation on bone immune microenvironment in detail.