文献类型：期刊文献

中文题名：干细胞源性细胞外囊泡在牙周再生治疗中的研究进展

英文题名：Advances in the study of stem cell-derived extracellular vesicles in periodontal regenerative therapy

作者：张秀丽[1];武曦(综述)[2];李昀生(审校)[3]

第一作者：张秀丽

机构：[1]北京联合大学门诊部口腔科,北京100101;[2]陆军军医大学第二附属医院口腔科,重庆400037;[3]应急总医院口腔科,北京100028

第一机构：北京联合大学校医院

年份：2022

卷号：51

期号：7

起止页码：1216-1219

中文期刊名：重庆医学

外文期刊名：Chongqing medicine

收录：CSTPCD;;PubMed

基金：国家自然科学基金项目(81600873)。

语种：中文

中文关键词：干细胞;干细胞源性;细胞外囊泡;牙周再生

外文关键词：stem cells;stem cell-derived;extracellular vesicles;periodontal regeneration

摘要：干细胞是一类未分化的多功能细胞,由于具备高度自我更新和多向分化的能力,在再生医学中具有广泛的前景。干细胞源性细胞外囊泡是由干细胞分泌的一类脂质囊泡,内含RNA、蛋白质等生物活性物质,可以在细胞间传递信息,具有促进组织再生的作用。细胞外囊泡可以避免干细胞治疗的一些缺陷,如有效细胞数目不足及免疫原性问题,并且还具备诸多优势,包括易于获得、可长期存储、易于包装等,这为组织再生提供了无细胞治疗的全新前景。本文就干细胞源性细胞外囊泡的生物学特性、功能及其在牙周组织再生治疗中的机制及应用前景作一综述。
Stem cells are undifferentiated and multipotent cells which have the capability of self-renewal and can differentiate into various types of cells.Stem cell-derived extracellular vesicles are a class of lipid vesicles secreted by stem cells,which contain biologically active substances such as RNA and protein,which can transmit information between cells and have the effect of promoting tissue regeneration.Extracellular vesicles can avoid some of the pitfalls of stem cell therapy,such as insufficient number of effective cells and immunogenicity issues,and also have many advantages,including easy access,long-term storage,ease of packaging,etc.,which provides cell-free therapy new prospects for tissue regeneration.This review summarized biological characteristics and function of stem cell-derived extracellular vesicles,as well as the mechanisms and potential applications in periodontal regenerative treatment.