文献类型：期刊文献

英文题名：The progressive supranuclear palsy patients exhibited lower levels of serum cholesterol and protein levels: a retrospective study

作者：Wang, Guihong[1];Huo, Qing[2];Zhan, Jiong[3];Nie, Binbin[4,5,6];Shan, Baoci[4,5,6];Feng, Tau[1,7,8]

第一作者：Wang, Guihong

通讯作者：Feng, T[1];Huo, Q[2]

机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Ctr Neurodegenerat Dis, Dept Neurol, Beijing 100050, Peoples R China;[2]Beijing Union Univ, Biochem Engn Coll, Dept Biomed, Fatouxili 3 Reg 18, Beijing 100023, Peoples R China;[3]Beijing Tiantan Hosp, Neurosci Imaging Ctr, 6 TiantanXili, Beijing 100050, Peoples R China;[4]Chinese Acad Sci, Inst High Energy Phys, Div Nucl Technol & Applicat, Beijing 100049, Peoples R China;[5]Beijing Engn Res Ctr Radiog Tech & Equipment, Beijing 100049, Peoples R China;[6]CAS Ctr Excellence Brain Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China;[7]Capital Med Univ, Beijing Inst Brain Disorders, Parkinsons Dis Ctr, Beijing 100050, Peoples R China;[8]China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China

第一机构：Capital Med Univ, Beijing Tiantan Hosp, Ctr Neurodegenerat Dis, Dept Neurol, Beijing 100050, Peoples R China

通讯机构：[1]corresponding author), Capital Med Univ, Beijing Tiantan Hosp, Ctr Neurodegenerat Dis, Dept Neurol, Beijing 100050, Peoples R China;[2]corresponding author), Beijing Union Univ, Biochem Engn Coll, Dept Biomed, Fatouxili 3 Reg 18, Beijing 100023, Peoples R China.|[1141726]北京联合大学生物化学工程学院;[11417]北京联合大学;

年份：2016

卷号：9

期号：8

起止页码：16807-16811

外文期刊名：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE

收录：;Scopus(收录号：2-s2.0-84985937181);WOS:【SCI-EXPANDED(收录号:WOS:000385837700225)】；

基金：This study was sponsored by grants from National Natural Science Foundation of China, Grant No. 81571226 and No. 11475020; 2014 Beijing Natural Science Foundation - Beijing Institute of Science and Technology jointly funded projects L140006; the biological marker study of alpha - the synaptic core protein in lip gland at the early stage Parkinson's disease.

语种：英文

外文关键词：Serum cholesterol; serum protein; parkinson disease; progressive supranuclear palsy

摘要：Many studies have showed that the serum cholesterol levels existed significant difference between Parkinson's disease (PD) patients and health controls. However, the serum cholesterol level in progressive supranuclear palsy (PSP) has not been studied. The object of this paper was to examine the levels of serum cholesterol and protein of PSP and their change in the disease progression. 57 possible PSP patients were collected in Beijing Tiantan Hospital from 2002 to 2014. The serum cholesterol and protein level of 57 patients were compared with 89 age-and sex-matched controls. In the 57 PSP patients, 12 patients have been in hospital two or more times. The data of these 12 patients were further analyzed to explore the changes of serum total cholesterol (TC) or total protein (TP) with the course of disease. Our findings showed that the serum TC and TP levels in patients were significantly lower than control. Multivariate logistics regression analysis showed that both TP and TC were independently associated with PSP. The serum protein and cholesterol levels further reduced from first hospitalization to the last time. The results implied that the serum protein and serum cholesterol might played a critical role in the development of PSP.