文献类型：期刊文献

英文题名：Structural brain changes in the anterior cingulate cortex of major depressive disorder individuals with suicidal ideation: Evidence from the REST-meta-MDD project

作者：Yi, Zhiqiang[1];Xia, Luyao[2,3];Yi, Junfei[1];Jia, Yanfei[1];Wei, Luhua[4];Shen, Shengli[1];Wu, Nan[2,3];Wang, Dongmei[5,6];Zhou, Huixia[5,6];Li, Xingxing[5,6];Yan, Chao-Gan[5,6,7,8,9];Zhang, Xiang-Yang[10]

第一作者：Yi, Zhiqiang

通讯作者：Zhang, XY[1]

机构：[1]Peking Univ First Hosp, Dept Neurosurg, Beijing, Peoples R China;[2]Beijing Union Univ, Teachers Coll, Dept Psychol, Beijing, Peoples R China;[3]Beijing Union Univ, Learning & Psychol Dev Inst Children & Adolescents, Beijing, Peoples R China;[4]Peking Univ First Hosp, Neurol Dept, Beijing, Peoples R China;[5]Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China;[6]Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China;[7]Chinese Acad Sci, Inst Psychol, Int Big Data Ctr Depress Res, Beijing, Peoples R China;[8]Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China;[9]Chinese Acad Sci, Inst Psychol, Res Ctr Lifespan Dev Mind & Brain CLIMB, Beijing, Peoples R China;[10]Anhui Med Univ, Hefei Peoples Hosp 4, Anhui Mental Hlth Ctr, Affiliated Mental Hlth Ctr, Hefei, Peoples R China

第一机构：Peking Univ First Hosp, Dept Neurosurg, Beijing, Peoples R China

通讯机构：[1]corresponding author), Anhui Med Univ, Hefei Peoples Hosp 4, Anhui Mental Hlth Ctr, Affiliated Mental Hlth Ctr, Hefei, Peoples R China.

年份：2025

卷号：55

外文期刊名：PSYCHOLOGICAL MEDICINE

收录：;Scopus(收录号：2-s2.0-85217540206);WOS:【SSCI(收录号:WOS:001436810300001)，SCI-EXPANDED(收录号:WOS:001436810300001)】；

基金：This study supported by the Academic Research Projects of Beijing Union University (ZK10202301). The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

语种：英文

外文关键词：anterior cingulate cortex; gray matter volume; magnetic resonance imaging; major depressive disorder; suicidal ideation

摘要：Background. Suicidal ideation (SI) is very common in patients with major depressive disorder (MDD). However, its neural mechanisms remain unclear. The anterior cingulate cortex (ACC) region may be associated with SI in MDD patients. This study aimed to elucidate the neural mechanisms of SI in MDD patients by analyzing changes in gray matter volume (GMV) in brain structures in the ACC region, which has not been adequately studied to date. Methods. According to the REST-meta-MDD project, this study subjects consisted of 235 healthy controls and 246 MDD patients, including 123 MDD patients with and 123 without SI, and their structural magnetic resonance imaging data were analyzed. The 17-item Hamilton Depression Rating Scale (HAMD) was used to assess depressive symptoms. Correlation analysis and logistic regression analysis were used to determine whether there was a correlation between GMV of ACC and SI in MDD patients. Results. MDD patients with SI had higher HAMD scores and greater GMV in bilateral ACC compared to MDD patients without SI (all p < 0.001). GMV of bilateral ACC was positively correlated with SI in MDD patients and entered the regression equation in the subsequent logistic regression analysis. Conclusions. Our findings suggest that GMV of ACC may be associated with SI in patients with MDD and is a sensitive biomarker of SI.