文献类型：期刊文献

英文题名：Megahertz multi-parametric ophthalmic OCT system for whole eye imaging

作者：Hu, Yicheng[1,2,3];Feng, Yutao[1,4];Long, Xing[1];Zheng, Dongye[1,2,3];Liu, Gangjun[3];Lu, Yanye[2,5];Ren, Qiushi[1,2,3];Huang, Zhiyu[2,3]

第一作者：Hu, Yicheng

通讯作者：Liu, GJ[1]

机构：[1]Peking Univ, Coll Future Technol, Dept Biomed Engn, Beijing 100871, Peoples R China;[2]Peking Univ, Shenzhen Grad Sch, Inst Biomed Engn, Shenzhen 518055, Peoples R China;[3]Shenzhen Bay Lab, Inst Biomed Engn, Shenzhen 518071, Peoples R China;[4]Beijing Union Univ, Coll Biochem Engn, Beijing 100021, Peoples R China;[5]Peking Univ, Inst Med Technol, Hlth Sci Ctr, Beijing 100191, Peoples R China

第一机构：Peking Univ, Coll Future Technol, Dept Biomed Engn, Beijing 100871, Peoples R China

通讯机构：[1]corresponding author), Shenzhen Bay Lab, Inst Biomed Engn, Shenzhen 518071, Peoples R China.

年份：2024

卷号：15

期号：5

起止页码：3000-3017

外文期刊名：BIOMEDICAL OPTICS EXPRESS

收录：;EI(收录号：20241916073518);Scopus(收录号：2-s2.0-85192671035);WOS:【SCI-EXPANDED(收录号:WOS:001254867300002)】；

基金：Funding. National Natural Science Foundation of China (62394310,62394311, 82371112) ; Beijing Municipal Natural Science Foundation (Z210008) ; Shenzhen Science and Technology Program (KQTD20180412181221912) .

语种：英文

摘要：An ultrahigh -speed, wide -field OCT system for the imaging of anterior, posterior, and ocular biometers is crucial for obtaining comprehensive ocular parameters and quantifying ocular pathology size. Here, we demonstrate a multi -parametric ophthalmic OCT system with a speed of up to 1 MHz for wide -field imaging of the retina and 50 kHz for anterior chamber and ocular biometric measurement. A spectrum correction algorithm is proposed to ensure the accurate pairing of adjacent A -lines and elevate the A -scan speed from 500 kHz to 1 MHz for retinal imaging. A registration method employing position feedback signals was introduced, reducing pixel offsets between forward and reverse galvanometer scanning by 2.3 times. Experimental validation on glass sheets and the human eye confirms feasibility and efficacy. Meanwhile, we propose a revised formula to determine the "true" fundus size using all -axial length parameters from different fields of view. The efficient algorithms and compact design enhance system compatibility with clinical requirements, showing promise for widespread commercialization.