文献类型：期刊文献

英文题名：Lactobacillus rhamnosus MP108: Toxicological evaluation

作者：Zhang, Bo[1];Lynch, Barry[2];Zhao, Jian[1];Guo, Yu[1];Mak, Alastair[2]

第一作者：张波;张斌

通讯作者：Lynch, B[1]

机构：[1]Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing, Peoples R China;[2]Intertek Sci & Regulatory Consultancy, 2233 Argentia Rd,Suite 201, Mississauga, ON L5N 2X7, Canada

第一机构：北京联合大学生物化学工程学院|北京联合大学应用文理学院

通讯机构：[1]corresponding author), Intertek Sci & Regulatory Consultancy, 2233 Argentia Rd,Suite 201, Mississauga, ON L5N 2X7, Canada.

年份：2021

卷号：86

期号：1

起止页码：228-241

外文期刊名：JOURNAL OF FOOD SCIENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000596496000001)】；

基金：Financial support for the conduct of the studies was provided to Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing, China. Financial support was also provided to Intertek Scientific & Regulatory Consultancy, Mississauga, Canada for the preparation of the manuscript. In both cases, financial support was provided by Glac Biotech Co., Ltd. of Tainan City, Taiwan.

语种：英文

外文关键词：safety; lactobacillus rhamnosus; genotoxicity; rat

摘要：A lyophilized powder of Lactobacillus rhamnosus MP108, a strain isolated from infant feces, has been developed for potential as a probiotic. To assess safety, three genetic toxicity studies (Ames, in vivo mouse micronucleus, and in vivo mouse spermatocyte chromosome aberration assays) and one 90-day oral rat toxicity study were conducted. Lactobacillus rhamnosus MP108 had no activity in the Ames assay, with or without metabolic activation, up to the highest dose tested (5000 mu g/plate). Also, no evidence of genotoxicity was observed in the two in vivo genotoxicity assays up to the maximum dose tested of 5.6 g/kg body weight. Feeding of L. rhamnosus MP108 to SD rats at doses of 0, 0.25, 0.5, or 1.5 g/kg body weight/day had no statistically or biologically significant effects on any of the parameters measured. An evaluation of Lactobacillus spp. generally, and L. rhamnosus specifically, showed no indication of concern for translocation or pathogenicity. The results of the toxicology studies showed no indications for safety concerns. Practical Application Lactobacillus rhamnosus MP108 is a bacterium that shows potential as a probiotic. While this bacterium has been used in food and food production, a series of studies were conducted to provide further assurance that this particular strain of L. rhamnosus is safe.